Antirheumatic Therapy: Actions and Outcomes (Progress in by Richard O. Day, Daniel E. Furst, Piet L.C.M. van Riel, Barry

By Richard O. Day, Daniel E. Furst, Piet L.C.M. van Riel, Barry Bresnihan

This e-book offers a finished evaluate of disease-modifying antirheumatic medicinal drugs (DMARDs). The introductory basic chapters care for the chemistry of DMARDs, their use in treatment, pharmacoeconomics, and a survey of opinion leaders within the box; the next particular chapters signify every one agent with reference to mechanism of motion, remedy, pharmacology, efficacy, toxicity, and tracking. for every agent a few heritage is given, contemporary advancements and effect of the therapy on sufferers` caliber of existence and long term results are provided.

Show description

Read or Download Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research) PDF

Similar rheumatology books

Gene Therapy for Autoimmune and Inflammatory Diseases

This booklet addresses the most recent advances in viral and non-viral vectors, novel objectives and strategies for the therapy of autoimmune and inflammatory illness with a major concentration in pre-clinical trying out with brand new medical trials. the 1st part of the booklet bargains with present examine ways for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's affliction, a number of sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus.

Rheumatology nursing : a creative approach

The foundations, perform and evolution of rheumatology nursing / Sarah Ryan and Jackie Hill -- The musculoskeletal approach and the rheumatic ailments / Valerie Arthur and Jackie Hill -- The immune process and rheumatic illness / Susan Oliver -- Biochemical, haematological and medical tests within the rheumatic ailments / Jackie Hill -- The mental features of rheumatic ailment / Sarah Ryan -- the results of rheumatic illness on physique photograph and sexuality / Jackie Hill -- The social implications of rheumatic illness / Sarah Ryan -- discomfort and stiffness / Jackie Hill -- Fatigue and sleep / Christine White -- the outside and meals / Naomi Reay, Sally Smith and Jill Byrne -- Multidisciplinary staff care of the rheumatic sufferer / Pauline Fitzgerald -- medicinal drugs within the rheumatic ailments / Jo White and Domini Bryer -- Complementary interventions / Anne Cawthorn and Peter Mackereth -- Surgical interventions / Maureen Cox -- sufferer schooling / Jackie Hill -- Seamless fundamental and secondary care / Mandy Edwards -- Paediatric care / Gill Jackson

Musculoskeletal Ultrasonography in Rheumatic Diseases

This publication is a pragmatic and evidence-based consultant to appearing medical musculoskeletal ultrasound for sufferers struggling with quite a few rheumatic ailments. It represents the simplest present considering at the position of ultrasonography within the evaluate of pathology, prognosis and remedy of those problems.

Oxford Textbook of Vasculitis

The 3rd version of this definitive and highly-regarded reference paintings presents a complete evaluate of vasculitis, a desirable array of life-threatening and minor stipulations as a result of inflammatory syndromes and illnesses that impact the blood vessels. The textual content uniquely brings jointly options from either the organic and scientific features of vasculitis.

Extra resources for Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research)

Example text

Table 2 shows NNTs for selected RCTs of DMARDs and biologic agents [25, 31]. The table is not comprehensive and only provides data on a few selected trials as illustrations, but as can be seen, even with biologic therapies at least half of the patients with RA do not show a minimal clinically relevant response (ACR 20) that can be attributed to the drug: a NNT of 2 is interpreted as only one out of every two patients improving because of treatment. While clinical trials assess efficacy, observational studies evaluate effectiveness, not only if a drug can work, but also if it indeed works when used in the community at large.

With the increasing number of medical databases and the identification of new biologic markers, "smart computing" in decision-making is becoming a reality. Nomograms are devices based on algorithms and mathematical modeling, which predict probabilities of outcomes. They are increasingly being developed to provide decision-support using friendly interfaces, such as personal computers or personal digital assistants (PDAs). Several examples of nomograms to assist decision-making about interventions with high risk-benefit ratios have been published in oncology [101].

Gastroenterology 118: 705-713 Yocum DE, Furst DE, Kaine JL, Baldassare AR, Stevenson JT, Borton MA, Meng le-Gaw LJ, Schwatz BD, Wisemandle W, Mekki OA et al (2003) Efficacy and safety of tacrolimus in pat ients with rheumatoid arthritis: a doubl e blind tr ial. Arthritis Rheum 48: 3328 -333 7 Hu ai Q, Kim H-Y, Liu Y, Zhao Y, Mondragon A, Liu JO , Ke H (2002) Crystal structure of calcineurin- cyclophilin-cyclospor in shows common but distinct recognition of irnmunophilin-drug complexes. Proc Nat Acad Sci USA 99: 12037-12042 Me dicinal chemistry of the disease modifyin g ant i-r heumatic drugs 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Kean WF, Lock ClL, Howard-Lock HE (1991) Chirality in antirheumatic drugs.

Download PDF sample

Rated 4.68 of 5 – based on 43 votes